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Furthermore, anticholinergic medications, such as trihexyphenidyl, are used also in PD management but struggle to effectively cross the BBB and often exhibit non-specific binding, leading to undesirable peripheral effects such as dry mouth and cognitive impairment, particularly in elderly patients

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According to the massive Study of Women's Health Across the Nation (SWAN), sleep disorders affect up to 47 percent of perimenopausal women, and up to 60 percent of postmenopausal women

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